Biologically Active Constituents of a Polyphenol Extract from Geranium sanguineum L. with Anti-Influenza Activity

  title={Biologically Active Constituents of a Polyphenol Extract from Geranium sanguineum L. with Anti-Influenza Activity},
  author={Assen Pantev and Stefka Ivancheva and Lidija Staneva and Julia Serkedjieva},
  journal={Zeitschrift f{\"u}r Naturforschung C},
  pages={508 - 516}
From the aerial roots of the medicinal plant Geranium sanguineum L. a polyphenol-rich extract with strong anti-influenza activity has been isolated. [...] Key Method To investigate its active fractions, the extract was partitioned by solvents with increasing polarity. The n-BuOH fraction contained the majority of the in vitro antiviral activity; the EtOAc fraction was the most effective one in vivo.Expand
Preventive Effect of a Polyphenol-Rich Extract from Geranium sanguineum L. on Hepatic Drug Metabolism in Influenza Infected Mice
The decreased hepatic drug metabolism (predominately first phase) is one of the essential reasons for numerous side effects and for increased drug toxicity during influenza virus infection (IVI). TheExpand
Chemical composition and antimicrobial activity of the volatile oils of Geranium sanguineum L. and G. robertianum L. (Geraniaceae)
Volatile compounds of Geranium sanguineum and G. robertianum were isolated by hydrodistillation, analyzed in detail by GC and GC/MS and screened for their in vitro antibacterial and antifungalExpand
An evidence of selective inhibitory activity of plant extracts to examined lactic acid bacteria and it is a prerequisite for their incorporation in food fermentation that have a lot of economic value, as well as in helping improve human health. Expand
Free Radical Scavenging and Antimicrobial Activities of Some Geranium Species
There are 35 Geranium (Geraniaceae) species recorded in the Flora of Turkey1,2. Some Geranium (Geraniaceae) species are used as antidiabetic, hemostatic, antihemorrhoidal, antidiarrheic and for theExpand
Antioxidant and prooxidant properties of a polyphenol‐rich extract from Geranium sanguineum L. in vitro and in vivo
A polyphenol‐rich extract from Geranium sanguineum (PC) protected biological membranes due to its antioxidant capacity and reduced the accumulation of TBA‐reactive products in rat liver microsomes in inducible lipid peroxidation (LPO). Expand
Antioxidant activities of Geranium sanguineum L. polyphenolic extract in chemiluminescent model systems
Abstract The aim of this study is to assess the antioxidant activities of Geranium sanguineum polyphenolic extract in chemiluminescent model systems by calculating the constants of inhibition towardsExpand
Chapter 11 - Medicinal Herbs and Plant Extracts for Influenza: Bioactivity, Mechanism of Anti-influenza Effects, and Modulation of Immune Responses
Several mechanisms of antiviral activity against influenza virus have been proposed based on a series of in vitro and in vivo studies, and the proper immune responses and the mechanism of the inhibitory activities of medicinal herbs, plant extracts, or their bioactive compounds need to be studied in more detail. Expand
Anticancer activities of proanthocyanidins from the plant Urceola huaitingii and their synergistic effects in combination with chemotherapeutics.
Some proanthocyanidins, especially compound 7 possessing two doubly interflavonoid linkages, exhibited significant synergistic anticancer effects with some chemotherapeutics in multiple cancer cell lines. Expand
lavonoids from the Brazilian plant Croton betulaster inhibit the rowth of human glioblastoma cells and induce apoptosis aulo
This study investigated the effects of the flavonoids 5-hydroxy-7,4′-dimethoxyflavone, casticin, and penduletin, isolated from Croton betulaster Müll Arg., Euphorbiaceae, a plant utilized in popularExpand
Flavonoids from the Brazilian plant Croton betulaster inhibit the growth of human glioblastoma cells and induce apoptosis
The results indicate that flavonoids extracted from C. betulaster present antitumoral activity to glioblastoma cells, with penduletin proving to be the most potent of the tested flavonoid. Expand


Polyphenols from Bulgarian medicinal plants with anti-infectious activity.
Three Bulgarian medicinal plants--Geranium macrorrhizum, G. sanguineum, and Epilobium hirsutum were analyzed phytochemically and the effect of the extracts on the reproduction of influenza viruses in vitro, in ovo, and in vivo was established. Expand
In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L.
A polyphenolic complex, isolated from the Bulgarian medicinal plant Geranium sanguineum L., was shown to have selective anti-influenza activity in vitro and the selectivity of antiviral action was confirmed by the variation in sensitivity of different influenza viruses to PC and the selection of variants with reduced drug sensitivity. Expand
Novel antiviral agents: a medicinal plant perspective
There are innumerable potentially useful medicinal plants and herbs waiting to be evaluated and exploited for therapeutic applications against genetically and functionally diverse viruses families such as Retroviridae, Hepadnaviridae and Herpesviridae. Expand
Plant polyphenolic complex inhibits the reproduction of influenza and herpes simplex viruses.
A polyphenolic complex (PC), isolated from the Bulgarian medicinal plant Germanium sanguineum L., inhibited the reproduction of influenza virus types A and B in vitro and in ovo. It protected whiteExpand
Can ethnopharmacology contribute to the development of antiviral drugs?
The importance of the plant kingdom as a source of new antiviral substances will be illustrated by presenting a survey on plant-derived antirhinovirus and anti-HIV agents. Expand
In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase.
The results suggested that flavones, which have potent influenza virus sialidase inhibitory activity, have anti-influenza virus activity in vivo. Expand
The effect of an aqueous propolis extract, of rutin and of a rutin-quercetin mixture on experimental influenza virus infection in mice.
Propolis extract administered intranasally 3 hours before virus inoculation led to a reduction of the HA titers recorded in the lung suspensions from infected mice, but to no reduction in mortality or increase in mean survival length. Expand
Compounds with anti-HIV activity from plants.
  • P. Houghton
  • Biology, Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1996
Natural products are described which have shown activity against human immunodeficiency virus in vitro and are being tested clinically and may provide new leads for viral chemotherapy. Expand
Influenza virus-inhibitory effects of intraperitoneally and aerosol-administered SP-303, a plant flavonoid.
The phenolic biopolymer SP-303 was evaluated against experimentally induced influenza A (H1N1) virus infections in mice in a series of experiments and exhibited consistent but reversible hypothermia immediately after termination of treatment. Expand
Combined protective effect of an immunostimulatory bacterial preparation and rimantadine in experimental influenza A virus infection.
The combined application of CM with rimantadine resulted in synergistically increased protection, determined on the basis of virus lung titers, lung consolidation, mortality rates, protective indices, and survival times. Expand