Biological voyage of solid lipid nanoparticles: a proficient carrier in nanomedicine.

@article{Ali2016BiologicalVO,
  title={Biological voyage of solid lipid nanoparticles: a proficient carrier in nanomedicine.},
  author={H. Ali and S. Singh},
  journal={Therapeutic delivery},
  year={2016},
  volume={7 10},
  pages={
          691-709
        }
}
  • H. Ali, S. Singh
  • Published 2016
  • Materials Science, Medicine
  • Therapeutic delivery
This review projects the prospects and issues faced by solid lipid nanoparticles (SLNs) in current scenarios, specially related to its clinical implementation and effectiveness. We re-examine the basic concept of biobehavior and movement of SLNs as a nanomedicine carrier. The extensive survey of the uptake and absorption mechanism from different routes, distribution pattern, targeting efficiency, effect of surface functionalization on biodistribution, elimination pathways and toxic effects have… Expand
11 Citations
Solid lipid nanoparticles for enhanced oral absorption: A review.
TLDR
The central topic of this review is focusing on providing brief updates on SLNs for improving drug oral absorption with their evolutions in curing numerous ailments and highlighting the transversal mechanisms of SLNs across the gastrointestinal hurdles. Expand
Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs
Abstract In today's drug development world, combinatorial chemistry, high-throughput screening, and genomics have provided a technologic platform that produces a large number of new chemical entitiesExpand
Solid Lipid Nanoparticles for Duodenum Targeted Oral Delivery of Tilmicosin
TLDR
The combination of duodenum-targeted release and P-gp inhibitors was an effective method to improve the oral absorption of tilmicosin. Expand
Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis
TLDR
The preparation and optimization of 2-hydroxypropyl-β-cyclodextrin modified solid lipid nanoparticles (SLNs) based oral combinational cargo system of Amphotericin B and Paromomycin against murine VL suggests that the superiority of as-prepared m-DDSLNs as a promising approach towards the oral delivery of anti-leishmanial drugs. Expand
Biopharmaceutical and pharmacokinetic aspects of nanocarrier-mediated oral delivery of poorly soluble drugs
Abstract Many new chemical entities have limited water solubility and therefore show low and/or variable oral bioavailability. Among the various strategies to overcome this challenge,Expand
Formulation, characterization and in vitro anti-leishmanial evaluation of amphotericin B loaded solid lipid nanoparticles coated with vitamin B12-stearic acid conjugate.
TLDR
A promising vitamin B12-stearic acid conjugate coated solid lipid nanoparticles encapsulated with AmB is fabricated by a combination of double emulsion solvent evaporation and thermal sensitive hydrogel techniques to improve AmB bioavailability and overcome multiple barriers for oral delivery. Expand
Nanodelivery of nitazoxanide: impact on the metabolism of Taenia crassiceps cysticerci intracranially inoculated in mice.
TLDR
The remarkable metabolic modifications that occur in this in vivo model through the application of these developed nanosystems confirm their capability to deliver NTZ into targeted tissues. Expand
Formulation and Optimization of Nano Lipid Based Oral Delivery Systems for Arthritis
Rheumatoid arthritis is an autoimmune disease characterized by chronic synovitis that leads to tissue dysfunction as well as loss of complete function. There are several synthetic NSAIDs,Expand
Theranostic Applications of Nanomaterials for Ophthalmic Applications
The development of theranostic applications of nanomaterials has presented researchers with a new form of diagnosing and treating diseases, such as cancer, Diabetic Retinopathy, and Age-RelatedExpand
In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using Gastroplus™
In this work, we conducted pharmacokinetic studies and established the in vitro and in vivo correlation (IVIVC) of furosemide (FRS) loaded solid lipid nanoparticles (FSLN). A bioanalytical methodExpand
...
1
2
...

References

SHOWING 1-10 OF 146 REFERENCES
Absorption, pharmacokinetics and disposition properties of solid lipid nanoparticles (SLNs).
TLDR
This review will primarily focus on the absorption, pharmacokinetics and disposition properties of SLNs for their possible applications in drug delivery. Expand
Preparation, Characterization and Cell Based Delivery of Stavudine Surface Modified Lipid Nanoparticles
Previously it was shown that uncoated lipid nanoparticles of stavudine proved effective in targeting HIV viral sites in body. Therefore, the main objective of this work was to prepare andExpand
Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives
  • M. Üner, G. Yener
  • Materials Science, Medicine
  • International journal of nanomedicine
  • 2007
Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the earlyExpand
The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice.
TLDR
Results suggested that SLN tended to be preferentially delivered to the liver and Ta-G2SLN may further enhance liver targeting. Expand
Solid lipid nanoparticles: production, characterization and applications.
TLDR
An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented. Expand
Absorption, disposition and pharmacokinetics of solid lipid nanoparticles.
TLDR
The lipidic nature, as well as the relatively small particle size, of SLNs ensures sufficient affinity with the biomembranes, and results in improved absorption by either of the oral, transdermal, pulmonary, nasal, ocular, rectal or buccal route. Expand
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
  • R. Müller, K. Mäder, S. Gohla
  • Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2000
TLDR
Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed. Expand
Effect of poloxamer 188 on lymphatic uptake of carvedilol-loaded solid lipid nanoparticles for bioavailability enhancement
TLDR
Findings augur well with the possibility of enhancement of the oral bioavailability of drug, via the lymphatic system bypassing hepatic first pass metabolism, via a combination of particle size as well as reduction in hydrophobicity of SLNs. Expand
Immunotoxicity derived from manipulating leukocytes with lipid-based nanoparticles.
  • D. Peer
  • Biology, Medicine
  • Advanced drug delivery reviews
  • 2012
TLDR
Deep understanding of how LNPs elicit immune responses is essential for the optimization of these systems for various biomedical applications and the different immune toxicities reported and proposed ways to manipulate leukocytes' functions using LNPS are detailed. Expand
Preparation and passive target of 5-fluorouracil solid lipid nanoparticles
TLDR
The results indicated that 5-FU-SLNs were promising passive targeting therapeutic agents for curing primary lung carcinoma and could improve therapeutic efficacy and reduce side-effects. Expand
...
1
2
3
4
5
...