Biological variation of prostate specific antigen levels in serum: an evaluation of day-to-day physiological fluctuations in a well-defined cohort of 24 patients.

@article{Nixon1997BiologicalVO,
  title={Biological variation of prostate specific antigen levels in serum: an evaluation of day-to-day physiological fluctuations in a well-defined cohort of 24 patients.},
  author={Randy G Nixon and Mark H. Wener and Kelly M. Smith and R. E. Parson and Susan A Strobel and Michael K. Brawer},
  journal={The Journal of urology},
  year={1997},
  volume={157 6},
  pages={2183-90}
}
PURPOSE We evaluated the daily biological variation of serum prostate specific antigen (PSA) concentrations to determine the critical difference required between 2 consecutive PSA measurements that would indicate a significant elevation. MATERIALS AND METHODS A total of 24 men, grouped according to clinical diagnosis and PSA, underwent phlebotomy for 10 consecutive weekdays. Duplicate serum samples were measured using 3 separate lots of Tandem-E and IMx PSA assays. The biological variation… CONTINUE READING

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