• Corpus ID: 15557924

Biological timekeeping in the presence of stochasticity

  title={Biological timekeeping in the presence of stochasticity},
  author={Farshid Jafarpour and Michael Vennettilli and Srividya Iyer-Biswas},
  journal={arXiv: Molecular Networks},
Causal ordering of key events in the cell cycle is essential for proper functioning of an organism. Yet, it remains a mystery how a specific temporal program of events is maintained despite ineluctable stochasticity in the biochemical dynamics which dictate timing of cellular events. We propose that if a change of cell fate is triggered by the {\em time-integral} of the underlying stochastic biochemical signal, rather than the original signal, then a dramatic improvement in temporal specificity… 

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