Biological synthesis of lanosterol and agnosterol.

@article{Clayton1956BiologicalSO,
  title={Biological synthesis of lanosterol and agnosterol.},
  author={R. Clayton and K. Bloch},
  journal={The Journal of biological chemistry},
  year={1956},
  volume={218 1},
  pages={
          305-18
        }
}
  • R. Clayton, K. Bloch
  • Published 1956
  • Medicine, Biology
  • The Journal of biological chemistry
  • There is considerable experimental evidence in support of the view that, in the biogenesis of cholesterol, squalene is an intermediate (1, 2). It has been suggested (3) that the cyclization of the aliphatic triterpenoid hydrocarbon to the tetracyclic ring system of the steroids occurs in a manner which would also rationalize the structure of lanosterol, a naturally occurring 4,4’, 14-trimethylcholestane derivative (4). In view of its structural relationship to squalene on the one hand and to… CONTINUE READING
    43 Citations
    The Biological Synthesis of Cholesterol11
    • 28
    The biosynthesis of squalene and sterols in fish.
    • 20
    The H-migration in the alkylation of sterols at C-24.
    • 32
    Studies on biosynthesis of cholesterol. IX. Zymosterol as a precursor of cholesterol.
    • 14
    Inhibitory Effect of “Isocholesterol” on the Absorption of Cholesterol
    • 3
    • PDF

    References

    by gest on O cber 28
    • physiol. Chem.,
    • 1936