• DOI:10.1016/s0021-9258(18)65894-6
Corpus ID: 19061263

Biological synthesis of lanosterol and agnosterol.

@article{Clayton1956BiologicalSO,
  title={Biological synthesis of lanosterol and agnosterol.},
  author={R. Clayton and K. Bloch},
  journal={The Journal of biological chemistry},
  year={1956},
  volume={218 1},
  pages={
          305-18
        }
}

R. Clayton, K. Bloch

Published 1956

Medicine, Biology

The Journal of biological chemistry

There is considerable experimental evidence in support of the view that, in the biogenesis of cholesterol, squalene is an intermediate (1, 2). It has been suggested (3) that the cyclization of the aliphatic triterpenoid hydrocarbon to the tetracyclic ring system of the steroids occurs in a manner which would also rationalize the structure of lanosterol, a naturally occurring 4,4’, 14-trimethylcholestane derivative (4). In view of its structural relationship to squalene on the one hand and to… CONTINUE READING

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