Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.

Abstract

Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.

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@article{Calabrese2007BiologicalSR, title={Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.}, author={Edward J. Calabrese and Kenneth A Bachmann and A. John Bailer and Philip Michael Bolger and Jonathan B Borak and Lu Cai and Nina Cedergreen and Mathew Cherian and Chuang Chin Chiueh and Thomas W. Clarkson and Ralph R. Cook and David M . Diamond and David J. Doolittle and Michael A Dorato and Stephen O Duke and Ludwig Emil Feinendegen and Donald E. Gardner and Ronald W. Hart and Kenneth L Hastings and Aw Hayes and George R. Hoffmann and John A . Ives and Zbigniew Jaworowski and Thomas Eugene Johnson and Wayne B. Jonas and Norbert E. Kaminski and John G. Keller and James E. Klaunig and Thomas B Knudsen and Walter J. Kozumbo and Teresa Lettieri and Shu-zheng Liu and Andre Maisseu and Kenneth I Maynard and Edward J. Masoro and Roger O. McClellan and Harihara M. Mehendale and Carmel Mothersill and David B. Newlin and Herbert N. Nigg and Frederick W. Oehme and Robert F. Phalen and Martin A. Philbert and Suresh I S Rattan and Jim E. Riviere and Joseph D Rodricks and Robert Morris Sapolsky and Bobby R . Scott and Colin B Seymour and David A. Sinclair and Joan Smith-Sonneborn and Elizabeth T. Snow and Linda Patia Spear and Donald E. Stevenson and Yol{\`e}ne Thomas and Maurice Tubiana and Gary M Williams and Mark P. Mattson}, journal={Toxicology and applied pharmacology}, year={2007}, volume={222 1}, pages={122-8} }