Biological significance of unwinding capability of nuclear matrix-associating DNAs.

  title={Biological significance of unwinding capability of nuclear matrix-associating DNAs.},
  author={J{\"u}rgen Bode and Y Kohwi and Liliane Dickinson and Toshio Joh and D Klehr and Christian Mielke and Terumi Kohwi-Shigematsu},
  volume={255 5041},
Matrix attachment regions (MARs) are thought to separate chromatin into topologically constrained loop domains. A MAR located 5' of the human beta-interferon gene becomes stably base-unpaired under superhelical strain, as do the MARs flanking the immunoglobulin heavy chain gene enhancer; in both cases a nucleation site exists for DNA unwinding. Concatemerized oligonucleotides containing the unwinding nucleation site exhibited a strong affinity for the nuclear scaffold and augmented SV40… CONTINUE READING

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