Biological significance of the CpG island methylator phenotype.

@article{Suzuki2014BiologicalSO,
  title={Biological significance of the CpG island methylator phenotype.},
  author={Hiromu Suzuki and Eiichiro Yamamoto and Reo Maruyama and Takeshi Niinuma and Masahiro Kai},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={455 1-2},
  pages={35-42}
}
Cancers exhibiting the CpG island methylator phenotype (CIMP) are found among a wide variety of human malignancies and represent a subclass of tumors showing concurrent hypermethylation of multiple CpG islands. These CIMP-positive tumors often exhibit characteristic molecular and clinicopathological features, suggesting CIMP represents a distinct carcinogenic pathway. However, marker genes to define CIMP have been largely inconsistent among studies, which has caused results to vary. Nonetheless… CONTINUE READING

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