Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion.

@article{Sood2004BiologicalSO,
  title={Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion.},
  author={Anil Sood and Jeremy E Coffin and Galen B Schneider and Mavis S. Fletcher and Barry R Deyoung and Lynn M. Gruman and David M. Gershenson and Michael D Schaller and Mary J. C. Hendrix},
  journal={The American journal of pathology},
  year={2004},
  volume={165 4},
  pages={1087-95}
}
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is activated by integrin clustering. There are limited data regarding the functional role of FAK in ovarian cancer migration and invasion. In the current study, FAK expression was evaluated in ovarian cell lines (nontransformed and cancer), 12 benign ovarian samples, and in 79 invasive epithelial ovarian cancers. All three ovarian cancer cell lines overexpressed FAK compared to the nontransformed cells. The dominant-negative… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 105 extracted citations

Signal transduction by focal adhesion kinase in cancer

Cancer and Metastasis Reviews • 2008
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…