Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.

@article{Leiper1999BiologicalSO,
  title={Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.},
  author={James M. Leiper and Patrick J. T. Vallance},
  journal={Cardiovascular research},
  year={1999},
  volume={43 3},
  pages={542-8}
}
The guanidino-methylated arginine analogue NG monomethyl-L-arginine (L-NMMA) has been the standard nitric oxide synthase inhibitor used to evaluate the role of the L-arginine:nitric oxide pathway. However, L-NMMA and other methylated arginine residues are also synthesised in vivo by the action of a family of enzymes known as protein arginine methyltransferases. Proteolysis of proteins containing methylated arginine residues releases free methylarginine residues into the cytosol from where they… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 157 extracted citations

Safety of long-term dietary supplementation with l-arginine in rats

Amino Acids • 2015
View 9 Excerpts
Highly Influenced

Arginine de novo and nitric oxide production in disease states.

American journal of physiology. Endocrinology and metabolism • 2012
View 7 Excerpts
Highly Influenced

Nitric oxide and atherosclerosis: an update.

Nitric oxide : biology and chemistry • 2006
View 12 Excerpts
Highly Influenced

Plasma Asymmetric Dimethylarginine ( ADMA ) in Relation to Cardiovascular

O DistributionBookshopTAJUP., Docent Reijo Laaksonen
2005
View 15 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…