Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.

  title={Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.},
  author={James M. Leiper and Patrick J. T. Vallance},
  journal={Cardiovascular research},
  volume={43 3},
The guanidino-methylated arginine analogue NG monomethyl-L-arginine (L-NMMA) has been the standard nitric oxide synthase inhibitor used to evaluate the role of the L-arginine:nitric oxide pathway. However, L-NMMA and other methylated arginine residues are also synthesised in vivo by the action of a family of enzymes known as protein arginine methyltransferases. Proteolysis of proteins containing methylated arginine residues releases free methylarginine residues into the cytosol from where they… CONTINUE READING
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