Biological significance of divalent metal ion binding to 14-3-3 proteins in relationship to nitrate reductase inactivation.

  title={Biological significance of divalent metal ion binding to 14-3-3 proteins in relationship to nitrate reductase inactivation.},
  author={G. S. Athwal and J. Huber and S. Huber},
  journal={Plant & cell physiology},
  volume={39 10},
  • G. S. Athwal, J. Huber, S. Huber
  • Published 1998
  • Chemistry, Medicine
  • Plant & cell physiology
  • In this report we address two questions regarding the regulation of phosphorylated nitrate reductase (pNR; EC by 14-3-3 proteins. The first concerns the requirement for millimolar concentrations of a divalent cation in order to form the inactive pNR:14-3-3 complex at pH 7.5. The second concerns the reduced requirement for divalent cations at pH 6.5. In answering these questions we highlight a possible general mechanism involved in the regulation of 14-3-3 binding to target proteins. We… CONTINUE READING
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