Biological significance of dermal Merkel cells in development of cutaneous nerves in human fetal skin.

@article{Narisawa1992BiologicalSO,
  title={Biological significance of dermal Merkel cells in development of cutaneous nerves in human fetal skin.},
  author={Yutaka Narisawa and Ken Hashimoto and Yoshiaki Nihei and Teresa Pietruk},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1992},
  volume={40 1},
  pages={65-71}
}
We detected epidermal Merkel cells in 12-week fetuses with monoclonal antibodies (MAb) against simple epithelium keratin and epithelial membrane antigen. In 15-week fetuses these Merkel cells began to descend into the dermis and expressed nerve growth factor receptors (NGF-R). At approximately the same time, cutaneous nerves, as detected with an MAb against neurofilaments, extended from the subcutaneous trunk and branched to form the subepidermal nerve plexus. The expression of NGF-R on dermal… CONTINUE READING