Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication.

@article{Wu2010BiologicalSO,
  title={Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication.},
  author={Chunchen Wu and Xiaoyong Zhang and Yongjun Tian and Jianhua Song and Dongliang Yang and Michael Roggendorf and Mengji Lu and Xinwen Chen},
  journal={The Journal of general virology},
  year={2010},
  volume={91 Pt 2},
  pages={483-92}
}
Amino acid substitutions of hepatitis B surface antigen (HBsAg) may affect the antigenicity and immunogenicity of HBsAg, leading to immune escape and diagnostic failure. The amino acid positions 122 and 160 are known as determinants for HBsAg subtypes d/y and w/r, respectively. The substitution K122I has been shown to strongly affect HBsAg antigenicity. In this study, we investigated the significance of naturally occurring amino acid substitutions K122I, T123N, A159G and K160N. Both T123N and… CONTINUE READING
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