Biological roles of sulfoglycolipids and pathophysiology of their deficiency

@article{Honke2004BiologicalRO,
  title={Biological roles of sulfoglycolipids and pathophysiology of their deficiency},
  author={Koichi Honke and Yanglong Zhang and Xinyao Cheng and Norihiro Kotani and Naoyuki Taniguchi},
  journal={Glycoconjugate Journal},
  year={2004},
  volume={21},
  pages={59-62}
}
Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO3-3Gal-ceramide) and seminolipid (SO3-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is expressed on the spermatogenic cells. Cerebroside sulfotransferase (CST)-deficient mice generated by gene targeting completely lack sulfatide and seminolipid all over the body. CST-null mice manifest some neurological disorders due to myelin dysfunction, an aberrant enhancement of oligodendrocyte… 
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Role of sulfatide in normal and pathological cells and tissues
TLDR
The important biological roles of sulfatide in the nervous system, insulin secretion, immune system, hemostasis/thrombosis, cancer, and microbial infections including human immunodeficiency virus and influenza A virus are discussed.
Biological functions of sulfoglycolipids and the EMARS method for identification of co-clustered molecules in the membrane microdomains.
  • K. Honke
  • Chemistry, Medicine
    Journal of biochemistry
  • 2018
TLDR
Analysis of CST-null mice has revealed that sulfatide is an essential component for the axo-glial junction at the paranode region and regulates terminal differentiation of oligodendrocytes, and that seminolipid is responsible for the formation of a functional lactate transporter assembly to take up the critical energy source for spermatocytes.
Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction.
TLDR
If subfertility in males with gene mutations in SGG/SGC metabolism pathways manifests prior to neurological disorder, sperm SGG levels might be used as a reporting/predicting index of the neurological status.
Increasing Sulfatide Synthesis in Myelin-Forming Cells of Arylsulfatase A-Deficient Mice Causes Demyelination and Neurological Symptoms Reminiscent of Human Metachromatic Leukodystrophy
TLDR
Growing sulfatide storage in ASA(−/−) mice leads to neurological symptoms and morphological alterations that are reminiscent of human MLD, and the approach described here may also be applicable to improve other mouse models of lysosomal as well as nonlysosomal disorders.
Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice
TLDR
PPARα activation enhances hepatic sulfatide synthesis via CST induction and implicate CST as a novel PPARα target gene, suggesting a protective role for serum sulfatides against arteriosclerosis and hypercoagulation.
GLYCOSPHINGOLIPID SULFATES STRUCTURE , OCCURRENCE , BIOLOGY AND ANALYSIS 1 . Occurrence and Structure
Glycosphingolipid sulfates (sometimes termed “sulfatides” or “sulfoglycosphingolipids”) are glycosphingolipids carrying a sulfate ester group attached to the carbohydrate moiety. They were first…
The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition.
TLDR
Cell functions and mechanisms of sulfatide recognition are overviewed to better understand the role of these lipids in health and disease and whether they might prove useful as novel biomarkers.
Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
TLDR
It is suggested thatPPARα activation induces CST gene expression and enhances sulfatide synthesis in mice, which suggests that PPARα is a possible transcriptional regulator for the mouse CST gene.
Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
TLDR
This study suggests that the crosstalk between kidney dysfunction and hepatic sulfatide metabolism is mediated by oxidative stress, which should help to understand the phenomenon in patients with end-stage kidney disease.
Sulfatide with short fatty acid dominates in astrocytes and neurons
TLDR
It is concluded that the major fatty acid composition of sulfatide differs between white and grey matter, with neurons and astrocytes containing mostly short‐chain fatty acids with an emphasis on stearic acid.
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