Biological roles of sulfoglycolipids and pathophysiology of their deficiency

@article{Honke2004BiologicalRO,
  title={Biological roles of sulfoglycolipids and pathophysiology of their deficiency},
  author={Koichi Honke and Yanglong Zhang and Xinyao Cheng and Norihiro Kotani and Naoyuki Taniguchi},
  journal={Glycoconjugate Journal},
  year={2004},
  volume={21},
  pages={59-62}
}
Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO3-3Gal-ceramide) and seminolipid (SO3-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is expressed on the spermatogenic cells. Cerebroside sulfotransferase (CST)-deficient mice generated by gene targeting completely lack sulfatide and seminolipid all over the body. CST-null mice manifest some neurological disorders due to myelin dysfunction, an aberrant enhancement of oligodendrocyte… 
Role of sulfatide in normal and pathological cells and tissues
TLDR
The important biological roles of sulfatide in the nervous system, insulin secretion, immune system, hemostasis/thrombosis, cancer, and microbial infections including human immunodeficiency virus and influenza A virus are discussed.
Biological functions of sulfoglycolipids and the EMARS method for identification of co-clustered molecules in the membrane microdomains.
  • K. Honke
  • Chemistry, Medicine
    Journal of biochemistry
  • 2018
TLDR
Analysis of CST-null mice has revealed that sulfatide is an essential component for the axo-glial junction at the paranode region and regulates terminal differentiation of oligodendrocytes, and that seminolipid is responsible for the formation of a functional lactate transporter assembly to take up the critical energy source for spermatocytes.
Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction.
TLDR
If subfertility in males with gene mutations in SGG/SGC metabolism pathways manifests prior to neurological disorder, sperm SGG levels might be used as a reporting/predicting index of the neurological status.
Increasing Sulfatide Synthesis in Myelin-Forming Cells of Arylsulfatase A-Deficient Mice Causes Demyelination and Neurological Symptoms Reminiscent of Human Metachromatic Leukodystrophy
TLDR
Growing sulfatide storage in ASA(−/−) mice leads to neurological symptoms and morphological alterations that are reminiscent of human MLD, and the approach described here may also be applicable to improve other mouse models of lysosomal as well as nonlysosomal disorders.
Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice
TLDR
PPARα activation enhances hepatic sulfatide synthesis via CST induction and implicate CST as a novel PPARα target gene, suggesting a protective role for serum sulfatides against arteriosclerosis and hypercoagulation.
GLYCOSPHINGOLIPID SULFATES STRUCTURE , OCCURRENCE , BIOLOGY AND ANALYSIS 1 . Occurrence and Structure
Glycosphingolipid sulfates (sometimes termed “sulfatides” or “sulfoglycosphingolipids”) are glycosphingolipids carrying a sulfate ester group attached to the carbohydrate moiety. They were first
The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition.
TLDR
Cell functions and mechanisms of sulfatide recognition are overviewed to better understand the role of these lipids in health and disease and whether they might prove useful as novel biomarkers.
Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
TLDR
It is suggested thatPPARα activation induces CST gene expression and enhances sulfatide synthesis in mice, which suggests that PPARα is a possible transcriptional regulator for the mouse CST gene.
Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
TLDR
This study suggests that the crosstalk between kidney dysfunction and hepatic sulfatide metabolism is mediated by oxidative stress, which should help to understand the phenomenon in patients with end-stage kidney disease.
Sulfatide with short fatty acid dominates in astrocytes and neurons
TLDR
It is concluded that the major fatty acid composition of sulfatide differs between white and grey matter, with neurons and astrocytes containing mostly short‐chain fatty acids with an emphasis on stearic acid.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Paranodal junction formation and spermatogenesis require sulfoglycolipids
TLDR
Data show a critical role for sulfoglycolipids in myelin function and spermatogenesis in mice generated by gene targeting and whether sulfatide and seminolipid are biosynthesized in vivo by a single sulfotransferase.
Sulfatide is a negative regulator of oligodendrocyte differentiation: Development in sulfatide‐null mice
TLDR
It is concluded that primarily sulfatide, rather than GalC, is a key molecule for the negative regulation of oligodendrocyte terminal differentiation.
Requirement of Seminolipid in Spermatogenesis Revealed by UDP-galactose:Ceramide Galactosyltransferase-deficient Mice*
TLDR
Observations in the testis of the UDP-galactose:ceramide galactosyltransferase-deficient mouse provide the first experimental evidence that seminolipid is indeed essential for normal spermatogenesis and support the broader concept that cell surface glycolipids are important in cellular differentiation and cell-to-cell interaction.
Myelin Galactolipids Are Essential for Proper Node of Ranvier Formation in the CNS
TLDR
The data presented here indicate that GalC and sulfatide are essential in proper CNS node and paranode formation and that these lipids are important in ensuring proper axo-oligodendrocyte interactions.
Cerebroside Sulfotransferase Deficiency Ameliorates L-selectin-dependent Monocyte Infiltration in the Kidney after Ureteral Obstruction*
TLDR
Sulfatide is a major L-selectin-binding molecule in the kidney and that the interaction between L- selectin and sulfatide plays a critical role in monocyte infiltration into the kidney interstitium.
Negative Regulation of Oligodendrocyte Differentiation by Galactosphingolipids
TLDR
A model in which galactosphingolipids act as sensors and/or transmitters of environmental information, interacting with endogenous ligands to function as negative regulators of oligodendrocyte differentiation, monitoring the timely progress of Pro-OLs into terminally differentiating, myelin-producing oligodendedrocytes is presented.
A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster Formation
TLDR
Results indicate a critical role for sulfatide in proper localization and maintenance of ion channels clusters, whereas they do not appear to be essential for initial cluster formation of Na+ channels.
Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression.
  • S. Schulte, W. Stoffel
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
TLDR
A purification method from microsomes of myelinating rat brains that includes ion exchange, dye ligand, and lectin affinity chromatography is described, which suggests a common evolutionary origin of these enzymes.
cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase.
TLDR
It is shown that the CST gene is preferentially transcribed in stomach, small intestine, brain, kidney, lung, and testis, in that order, and RT-PCR analyses of CST mRNAs from various tissues confirmed that CST transcripts are tissue-specifically spliced by alternative use of multiple exons 1.2.8.
...
1
2
3
...