Biological roles of lysophospholipid receptors revealed by genetic null mice: an update.

Abstract

Two lysophospholipids (LPs), lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are known to affect various cellular events. Their actions are mediated by binding to at least ten bona fide high-affinity G protein-coupled receptors referred to as LPA1-5 and S1P1-5. These LPs are expressed throughout the body and are involved in a range of… (More)
DOI: 10.1016/j.bbalip.2008.03.004

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