Biological roles for the NOX family NADPH oxidases.

  title={Biological roles for the NOX family NADPH oxidases.},
  author={William M Nauseef},
  journal={The Journal of biological chemistry},
  volume={283 25},
Linking the phagocyte defect in patients with chronic granulomatous disease (CGD) with the biochemical basis for oxygen consumption by stimulated neutrophils (1) represented a seminal advance in understanding the molecular basis for a key component of innate immunity. In subsequent decades, the catalytic and regulatory elements of the “respiratory burst oxidase” were elucidated, tacitly assuming all along that the NADPHdependent oxidase under study represented a system uniquely expressed in… CONTINUE READING
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