Biological role of interleukin 1 receptor antagonist isoforms.

  title={Biological role of interleukin 1 receptor antagonist isoforms.},
  author={W P Arend and C J Guthridge},
  journal={Annals of the rheumatic diseases},
  volume={59 Suppl 1},
The interleukin 1 receptor antagonist (IL1Ra) family of molecules now includes one secreted isoform (sIL1Ra) and three intracellular isoforms (icIL1Ra1, 2, and 3). Extensive evidence indicates that the sole biological function of sIL1Ra seems to be to competitively inhibit IL1 binding to cell-surface receptors. Although intracellular IL1Ra1 may be released from keratinocytes under some conditions, the intracellular isoforms of IL1Ra may carry out additional as yet poorly defined roles inside… CONTINUE READING
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Interleukin - 1 â , interleukin - 1 receptor antagonist , interleukin - 4 , and interleukin - 10 gene polymorphisms . Relationship to occurrence and severity of rheumatoid arthritis

  • FE Clay, JK Tarlow, MJ Cork, A Cox, Nicklin MJH, GW DuV
  • Arthritis Rheum
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