Biological role of interleukin 1 receptor antagonist isoforms.

@article{Arend2000BiologicalRO,
  title={Biological role of interleukin 1 receptor antagonist isoforms.},
  author={W P Arend and C J Guthridge},
  journal={Annals of the rheumatic diseases},
  year={2000},
  volume={59 Suppl 1},
  pages={i60-4}
}
The interleukin 1 receptor antagonist (IL1Ra) family of molecules now includes one secreted isoform (sIL1Ra) and three intracellular isoforms (icIL1Ra1, 2, and 3). Extensive evidence indicates that the sole biological function of sIL1Ra seems to be to competitively inhibit IL1 binding to cell-surface receptors. Although intracellular IL1Ra1 may be released from keratinocytes under some conditions, the intracellular isoforms of IL1Ra may carry out additional as yet poorly defined roles inside… CONTINUE READING
49 Citations
47 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Interleukin - 1 â , interleukin - 1 receptor antagonist , interleukin - 4 , and interleukin - 10 gene polymorphisms . Relationship to occurrence and severity of rheumatoid arthritis

  • FE Clay, JK Tarlow, MJ Cork, A Cox, Nicklin MJH, GW DuV
  • Arthritis Rheum
  • 1999

Similar Papers

Loading similar papers…