Biological role of anaplastic lymphoma kinase in neuroblastoma.

@article{OsajimaHakomori2005BiologicalRO,
  title={Biological role of anaplastic lymphoma kinase in neuroblastoma.},
  author={Yuko Osajima-Hakomori and Izumi Miyake and Miki Ohira and Akira Nakagawara and Atsuko Nakagawa and Ryuichi Sakai},
  journal={The American journal of pathology},
  year={2005},
  volume={167 1},
  pages={
          213-22
        }
}

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References

SHOWING 1-10 OF 44 REFERENCES

Expression of the ALK tyrosine kinase gene in neuroblastoma.

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

TLDR
Molecular cloning of cDNAs for both the human and mouse ALK proteins reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain and shows the greatest sequence similarity to LTK (leukocyte tyrosine Kinase) whose biological function is presently unknown.

Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1.

TLDR
Results indicate that reliable immunostaining of routine biopsy material for NPM-ALK and ALK proteins is feasible and of diagnostic importance, especially because t(2;5)+ ALCL cases have a good prognosis with appropriate treatment.

Translocations involving anaplastic lymphoma kinase (ALK)

TLDR
This review will focus on the molecular function and signal transduction pathways activated by ALK fusion oncogenes, with recent advances and possible clinical implications to be discussed.

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

TLDR
It is shown that mAb16-39 elicits tyrosine phosphorylation of endogenously expressed ALK in human neuroblastoma (SK-N-SH) cells, indicating an essential role of the mitogen-activated protein kinase (MAP kinase) signaling cascade in ALK-mediated growth and differentiation of neurons.

Identification of Anaplastic Lymphoma Kinase as a Receptor for the Growth Factor Pleiotrophin*

TLDR
It is proposed that the PTN-ALK axis can play a significant role during development and during disease processes because of the growth stimulatory effect of PTN on different cell lines in culture coincides with the endogenous expression of ALK mRNA.

Midkine Binds to Anaplastic Lymphoma Kinase (ALK) and Acts as a Growth Factor for Different Cell Types*

TLDR
It is concluded that MK can act as a growth, survival, and angiogenic factor during tumorigenesis and signals through the ALK receptor.

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

TLDR
In the predicted hybrid protein, the amino terminus of nucleophosmin (NPM) is linked to the catalytic domain of anaplastic lymphoma kinase (ALK), and unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas.

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

Anaplastic Lymphoma Kinase (ALK) was originally identified as a member of the insulin receptor subfamily of receptor tyrosine kinases that acquires transforming capability when truncated and fused to

Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3.

TLDR
A unique phosphotyrosine-containing protein of MW 80,000, designated p80, was found only in AMS3 cells and not in other cell lines or mononuclear cells from healthy donors, and amino acid sequence analysis of its tryptic digests showed that p80 was a hitherto undescribed tyrosine phosphoprotein similar to Ltk (leukocyte tyrosinesine kinase).