Biological rhythms and melatonin in mood disorders and their treatments.

  title={Biological rhythms and melatonin in mood disorders and their treatments.},
  author={Laurence Lanfumey and Raymond Mongeau and Michel Hamon},
  journal={Pharmacology & therapeutics},
  volume={138 2},
Affective disorders such as major depression, bipolar disorders and seasonal affective disorders have been described as alterations of various neuronal systems. In addition to the classical monoaminergic hypotheses that have been long proposed to explain the pathophysiology of these disorders, a strong association between circadian rhythms and mood regulation has been suggested in the light of several clinical and preclinical findings. In this review, we summarize the different hypotheses on… CONTINUE READING
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