Biological properties of structurally related alpha-helical cationic antimicrobial peptides.

@article{Scott1999BiologicalPO,
  title={Biological properties of structurally related alpha-helical cationic antimicrobial peptides.},
  author={Monisha G. Scott and Hong Yan and Robert E. Hancock},
  journal={Infection and immunity},
  year={1999},
  volume={67 4},
  pages={2005-9}
}
A series of alpha-helical cationic antimicrobial peptide variants with small amino acid changes was designed. Alterations in the charge, hydrophobicity, or length of the variant peptides did not improve the antimicrobial activity, and there was no statistically significant correlation between any of these factors and the MIC for Pseudomonas aeruginosa, Escherichia coli, or Salmonella typhimurium. Individual peptides demonstrated synergy with conventional antibiotics against antibiotic-resistant… CONTINUE READING

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