Biological properties of simian virus 40 host range mutants lacking the COOH-terminus of large T antigen.

@article{Cole1987BiologicalPO,
  title={Biological properties of simian virus 40 host range mutants lacking the COOH-terminus of large T antigen.},
  author={Charles N. Cole and Terryl Stacy},
  journal={Virology},
  year={1987},
  volume={161 1},
  pages={
          170-80
        }
}
Three mutants of simian virus 40 (SV40), with deletions near the 3' end of the A gene, displayed a host range phenotype for growth and virus production in various African green monkey kidney cell lines. The mutants formed plaques in CV-1P cells at 40.5 degrees, in BSC-1 cells at 37 and 40.5 degrees, and in Vero cells at 32, 37, and 40.5 degrees. Virus yields in these three lines were cold sensitive: the burst size was greatest at 40.5 degrees and least at 32 degrees, but some progeny was… CONTINUE READING

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