Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model.

Abstract

We used a mouse nasal model of herpes simplex virus 2 (HSV-2) infection to examine the biological properties of HSV-2 wild-type (wt), TK-negative, and replication-defective strains in vivo. Nasal septa tissue is the major site of wt viral replication post intranasal (i.n.) inoculation. The HSV-2 strain 186 syn(+)-1 wt virus caused lethal encephalitis at… (More)

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@article{Jones2000BiologicalPO, title={Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model.}, author={C A Jones and Tiffani Taylor and David Michael Knipe}, journal={Virology}, year={2000}, volume={278 1}, pages={137-50} }