Biological properties of 8-methoxypyrimido[4(1),5(1):4,5]thieno(2,3-b)quinoline-4(3H)-one, a new class of DNA intercalating drugs.

@article{Gopal2004BiologicalPO,
  title={Biological properties of 8-methoxypyrimido[4(1),5(1):4,5]thieno(2,3-b)quinoline-4(3H)-one, a new class of DNA intercalating drugs.},
  author={Madhuban Gopal and Mohd. Shahabuddin},
  journal={The Indian journal of medical research},
  year={2004},
  volume={119 5},
  pages={198-205}
}
BACKGROUND & OBJECTIVES The compounds containing novel tetracyclic condensed quinoline ring system is of interest because of its close relationship with anticancer drug ellipticine. 8-Methoxypyrimido[4(1),5(1):4,5]thieno(2,3-b)quinoline-4(3H)-one (MPTQ) was investigated to study its effect on in vitro growth inhibition and clonogenic cell survival assay on three tumour cell lines, human promyelocytic leukemia HL-60, melanoma B16F10 and neuro 2a. A systematic study was carried out to evaluate… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Nonsteroidal antiinflammatory drugs in colorectal cancer: from prevention to therapy

P Ricchi, R Zarrilli, A di Palma, AM. Acquaviva
Br J Cancer • 2003
View 1 Excerpt

Interaction between 8-methoxy pyrimido[41,51:4,5]thieno(2,3-b)quinoline-4(3H)one antitumour drug and deoxyribonucleic acid

M Gopal, MS Shahabuddin, SR. Inamdar
Proc Indian Acad Sci (Chem Sci) • 2002
View 1 Excerpt

Antiinflammatory activity of the volatile oil of Toddalia asiatica

S Kavimani, T Vetrichelvan, R Ilango, B. Jayakar
Indian J Pharm Sci • 1996

2,10disubstituted phenothiazine as antiinflammatory agents

A Kumar, RS Verma, KK Saxena, VK. Srivastava
J Indian Chem Soc 1994; • 1994
View 1 Excerpt

Preclinical phase II studies in human tumor xenografts: a European multicenter follow-up study.

Annals of oncology : official journal of the European Society for Medical Oncology • 1994

Synthesis of 2-aryl–1,2,3,4tetrahydro pyrido[21,31:4,5]thieno[2,3-b]quinolin-4-ones

SK Nandeeshaiah, SY Ambeker
Indian J Chem • 1994

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