Biological processes in benzodiazepine dependence.

  title={Biological processes in benzodiazepine dependence.},
  author={Malcolm H. Lader},
  volume={89 11},
The indications for the benzodiazepines include anxiety, insomnia, muscle spasm and epilepsy and each disorder has a variety of biological substrates. Limbic structures and the neurotransmitters noradrenaline, 5-HT and GABA have all been implicated. Benzodiazepines act on allosteric receptor sites and potentiate the actions of GABA in modulating chloride ionophores across nerve membranes. These effects can be blocked by the benzodiazepine antagonist, flumazenil. The molecular pharmacology of… CONTINUE READING

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