Biological phosphoryl-transfer reactions: understanding mechanism and catalysis.

  title={Biological phosphoryl-transfer reactions: understanding mechanism and catalysis.},
  author={Jonathan Kyle Lassila and Jesse G. Zalatan and Daniel Herschlag},
  journal={Annual review of biochemistry},
Phosphoryl-transfer reactions are central to biology. These reactions also have some of the slowest nonenzymatic rates and thus require enormous rate accelerations from biological catalysts. Despite the central importance of phosphoryl transfer and the fascinating catalytic challenges it presents, substantial confusion persists about the properties of these reactions. This confusion exists despite decades of research on the chemical mechanisms underlying these reactions. Here we review… CONTINUE READING