Biological mechanisms underlying the clinical effects of RU 486: modulation of cultured endometrial stromal cell stromelysin-1 and prolactin expression.

@article{Schatz1997BiologicalMU,
  title={Biological mechanisms underlying the clinical effects of RU 486: modulation of cultured endometrial stromal cell stromelysin-1 and prolactin expression.},
  author={Frederick Schatz and Csaba Papp and S. Aigner and Graciela Krikun and V A Hausknecht and Charles Joseph Lockwood},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 1},
  pages={
          188-93
        }
}
  • Frederick Schatz, Csaba Papp, +3 authors Charles Joseph Lockwood
  • Published in
    The Journal of clinical…
    1997
  • Biology, Medicine
  • During in vitro decidualization of human endometrial stromal cells (HESCs), medroxyprogesterone acetate (MPA) inhibits expression of the potent extracellular matrix (ECM)-degrading protease stromelysin-1 (MMP-3), but enhances PRL expression. Consistent with its priming role in vivo, estradiol (E2) augments these effects. In the current study, immunoblot analysis revealed that coincubation with 10(-6) M RU 486 blocked the inhibition in HESC-secreted MMP-3 levels (50,000 mol wt) evoked by 10(-8… CONTINUE READING

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