Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis.

@article{Denbesten1992BiologicalMO,
  title={Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis.},
  author={Pamela K Denbesten and H Thariani},
  journal={Journal of dental research},
  year={1992},
  volume={71 5},
  pages={1238-43}
}
Enamel fluorosis can occur following either an acute or chronic exposure to fluoride during tooth formation. Fluorosed enamel is characterized by a retention of amelogenins in the early-maturation stage, and by the formation of a more porous enamel with a subsurface hypomineralization. The mechanisms by which fluoride affects enamel development include specific effects on both the ameloblasts and on the developing enamel matrix. Maturation-stage ameloblast modulation is more rapid in fluorosed… CONTINUE READING
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