Biological markers of amyloid beta-related mechanisms in Alzheimer's disease.

  title={Biological markers of amyloid beta-related mechanisms in Alzheimer's disease.},
  author={Harald Hampel and Yong Shen and Dominic M Walsh and Paul S. Aisen and Les M. Shaw and Henrik Zetterberg and John Q. Trojanowski and K Blennow},
  journal={Experimental neurology},
  volume={223 2},
Recent research progress has given detailed knowledge on the molecular pathogenesis of Alzheimer's disease (AD), which has been translated into an intense, ongoing development of disease-modifying treatments. Most new drug candidates are targeted on inhibiting amyloid beta (Abeta) production and aggregation. In drug development, it is important to co-develop biomarkers for Abeta-related mechanisms to enable early diagnosis and patient stratification in clinical trials, and to serve as tools to… CONTINUE READING


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Alzheimer's disease

  • K. Blennow, M. J. de Leon, H. Zetterberg
  • Lancet
  • 2006
Highly Influential
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