Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cis-platinum.

@article{Boku1998BiologicalMA,
  title={Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cis-platinum.},
  author={Narikazu Boku and Khew-Voon Chin and Kouichi Hosokawa and Atsushi Ohtsu and Hisao Tajiri and Shigeaki Yoshida and Takekazu Yamao and Hidehiro Kondo and Kuniaki Shirao and Yasuhiro Shimada and Daizo Saito and Takahiro Hasebe and Kiyoshi Mukai and Sachiko Seki and Hiroshi Saito and Patrick Gerard Johnston},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1998},
  volume={4 6},
  pages={1469-74}
}
We investigated the utility of examining biological markers to predict chemoresponse and survival. The subjects consisted of 39 unresectable gastric cancer patients treated with a combination of 5-fluorouracil and cis-platinum. The expression of p53, bcl-2, thymidylate synthase (TS), glutathione S-transferase pi (GST-pi), and vascular endothelial growth factor (VEGF) in the formalin-fixed biopsy samples of primary tumors before chemotherapy was examined immunohistochemically. The positive rate… CONTINUE READING