Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets.

@article{Powell1999BiologicalIO,
  title={Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets.},
  author={William S Powell and Sylvie Gravel and Subhash P. Khanapure and Joshua Rokach},
  journal={Blood},
  year={1999},
  volume={93 3},
  pages={1086-96}
}
Neutrophil-derived 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent activator of neutrophils and eosinophils. In the present study we examined the biosynthesis and metabolism of this substance by platelets. Although platelets contain an abundant amount of 5-hydroxyeicosanoid dehydrogenase, the enzyme responsible for the formation of 5-oxo-ETE, they synthesize only very small amounts of this substance from exogenous 5-hydroxyeicosatetraenoic acid (5-HETE) unless endogenous NADPH is… CONTINUE READING

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Total synthesis of potent proinflammatory 5-oxo-ETE and its 6,7-dihydro biotransformation product

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