Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas

@article{Kersting2008BiologicalIO,
  title={Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas},
  author={C. Kersting and K. Agelopoulos and H. Schmidt and E. Korsching and C. August and G. Gosheger and U. Dirksen and H. Juergens and W. Winkelmann and B. Brandt and S. Bielack and H. Buerger and C. Gebert},
  journal={Genes},
  year={2008},
  volume={47}
}
Expression of EGFR in high grade osteosarcomas has been observed to be correlated with an improved prognosis. Yet, the underlying mechanism remained unclear since amplifications of EGFR have rarely been described. Recently, the length of a polymorphic CA repeat located at a 5′‐regulatory sequence in the intron 1 of the EGFR gene (SSR I) has been shown to be associated with its basal transcriptional activity. We therefore determined the allelic length of CA SSR‐I in 219 cases of high grade… Expand
15 Citations
EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance
SBMDb: first whole genome putative microsatellite DNA marker database of sugarbeet for bioenergy and industrial applications
Repeat performance: how do genome packaging and regulation depend on simple sequence repeats?
...
1
2
...

References

SHOWING 1-10 OF 32 REFERENCES
Modification of Breast Cancer Risk in Young Women by a Polymorphic Sequence in the egfr Gene
Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation.
  • Wu Zhang, D. Park, +8 authors H. Lenz
  • Medicine, Biology
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2005
Modulation of Epidermal Growth Factor Receptor Gene Transcription by a Polymorphic Dinucleotide Repeat in Intron 1*
Mechanisms of egfr Gene Transcription Modulation: Relationship to Cancer Risk and Therapy Response
Malignant astrocytoma‐derived region of common amplification in chromosomal band 17p12 is frequently amplified in high‐grade osteosarcomas
Epidermal Growth Factor Receptor Expression in High-Grade Osteosarcomas Is Associated with a Good Clinical Outcome
...
1
2
3
4
...