Biological implications of oxidation and unidirectional chiral inversion of D-amino acids.

  title={Biological implications of oxidation and unidirectional chiral inversion of D-amino acids.},
  author={Yongxiang Wang and Nian Gong and Yan-Fei Xin and Bin Hao and Xiang-jun Zhou and Catherine Cheuk Ying Pang},
  journal={Current drug metabolism},
  volume={13 3},
Recent progress in chiral separation of D- and L-amino acids by chromatography ascertained the presence of several free Damino acids in a variety of mammals including humans. Unidirectional chiral inversion of many D-amino acid analogs such as exogenous NG-nitro-D-arginine (D-NNA), endogenous D-leucine, D-phenylanine and D-methionine have been shown to take place with inversion rates of 4-90%, probably dependent on various species D-amino acid oxidase (DAAO) enzymatic activities. DAAO is known… 
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