Biological implications of isochore boundaries in the human genome.

@article{Zheng2008BiologicalIO,
  title={Biological implications of isochore boundaries in the human genome.},
  author={Wen-Xin Zheng and Chun-Ting Zhang},
  journal={Journal of biomolecular structure & dynamics},
  year={2008},
  volume={25 4},
  pages={327-36}
}
The human genome is composed of large sequence segments with fairly homogeneous GC content, namely isochores, which have been linked to many important functions; biological implications of most isochore boundaries, however, remain elusive, partly due to the difficulty in determining these boundaries at high resolution. Using the segmentation algorithm based… CONTINUE READING