Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.

@article{Schaefer2008BiologicalFO,
  title={Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.},
  author={Liliana Schaefer and Renato V Iozzo},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 31},
  pages={
          21305-9
        }
}
The small leucine-rich proteoglycan (SLRP) family has significantly expanded in the past decade to now encompass five discrete classes, grouped by common structural and functional properties. Some of these gene products are not classical proteoglycans, whereas others have new and unique features. In addition to being structural proteins, SLRPs constitute a network of signal regulation: being mostly extracellular, they are upstream of multiple signaling cascades. They affect intracellular… CONTINUE READING
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