Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding.

@article{Qian1992BiologicalFO,
  title={Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding.},
  author={Youcun Qian and C H Luckey and Lynn E. Horton and Markus Esser and Dennis J. Templeton},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 12},
  pages={5363-72}
}
Despite the importance of the retinoblastoma susceptibility gene to tumor growth control, the structural features of its encoded protein (pRb) and their relationship to protein function have not been well explored. We constructed a panel of deletion mutants of pRb expression vectors and used a biological assay for pRb that measures growth inhibition and morphologic changes in pRb-transfected Saos-2 cells to correlate structural alterations of the pRb coding region with function. We tested the… CONTINUE READING

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