Biological function in the twilight zone of sequence conservation

  title={Biological function in the twilight zone of sequence conservation},
  author={Chris Paul Ponting},
  booktitle={BMC Biology},
Strong DNA conservation among divergent species is an indicator of enduring functionality. With weaker sequence conservation we enter a vast ‘twilight zone’ in which sequence subject to transient or lower constraint cannot be distinguished easily from neutrally evolving, non-functional sequence. Twilight zone functional sequence is illuminated instead by principles of selective constraint and positive selection using genomic data acquired from within a species’ population. Application of these… CONTINUE READING
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