Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes.

@article{Rich1973BiologicalEO,
  title={Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes.},
  author={Robert Rich and Carl W. Pierce},
  journal={The Journal of experimental medicine},
  year={1973},
  volume={137 3},
  pages={
          649-59
        }
}
A population of thymus-derived lymphocytes has been identified that, upon activation by the nonspecific plant mitogen concanavalin A, suppresses the development of plaque-forming cell responses in fresh or 48-h antigen-stimulated cultures of mouse spleen cells. Suppressor cells can inhibit both primary and secondary IgM and IgG responses in vitro. X-irradiation before activation of peripheral thymus-derived cells by concanavalin A abrogates generation of suppressor cells. After a 48 h… CONTINUE READING

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