Biological evaluation on different human cancer cell lines of novel colchicine analogs.

Abstract

Three new 7-0-substituted deacetamidothiocolchicine derivatives have been evaluated for their antitumor activity against various human tumor cell lines, some of which express the multidrug resistance (MDR) phenotype, for their impact on the cell cycle and their binding to tubulin. Colchicine and thiocolchicine were used as reference compounds… (More)

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Cite this paper

@article{Vincenzo1999BiologicalEO, title={Biological evaluation on different human cancer cell lines of novel colchicine analogs.}, author={Rosa I De Vincenzo and Christiano Ferlini and M G Distefano and Cristiana Gaggini and Antonella Riva and Egidio Bombardelli and Paolo Morazzoni and Bruno Danieli and Gioia Capelli and Salvatore Mancuso and Giovanni Scambia}, journal={Oncology research}, year={1999}, volume={11 3}, pages={145-52} }