Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2′-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation

Abstract

A series of chloro-substituted-2′-hydroxychalcones were prepared and evaluated for their cytotoxic effects against K562 and SK-N-MC human cancer cell lines and as the inhibitors of tubulin polymerization. The 3,5′-dichloro- analogue (compound 3) inhibited the assembly of protofilaments with 89% inhibition. Compound 3 was found to be bound to tubulin with a dissociation constant of 3.7 μM and altered far-UV circular dichroism spectrum of tubulin and altered far-UV circular dichroism spectrum of tubulin.

DOI: 10.1007/s00044-010-9344-z

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Cite this paper

@article{Aryapour2010BiologicalEO, title={Biological evaluation of synthetic analogues of curcumin: chloro-substituted-2′-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation}, author={Hassan Aryapour and Gholamhossein Riazi and Alireza Foroumadi and Shahin Ahmadian and Abbass Shafiee and Oveis Karima and Majid Mahdavi and Saeed Emami and Maedeh Sorkhi and Sirus Khodadady}, journal={Medicinal Chemistry Research}, year={2010}, volume={20}, pages={503-510} }