Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others

@article{Tokunaga2017BiologicalEO,
  title={Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others},
  author={Etsuko Tokunaga and Hidehiko Akiyama and Vadim A. Soloshonok and Yuki Inoue and Hideaki Hara and Norio Shibata},
  journal={PLoS ONE},
  year={2017},
  volume={12}
}
Over the last few years, thalidomide has become one of the most important anti-tumour drugs for the treatment of relapsed-refractory multiple myeloma. However, besides its undesirable teratogenic side effect, its configurational instability critically limits any further therapeutic improvements of this drug. In 1999, we developed fluoro-thalidomide which is a bioisostere of thalidomide, but, in sharp contrast to the latter, it is configurationally stable and readily available in both… Expand
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