Biological evaluation of 99mTc-ethambutol for early detection of tuberculosis infection in animal model

@article{Juwita2009BiologicalEO,
  title={Biological evaluation of 99mTc-ethambutol for early detection of tuberculosis infection in animal model},
  author={Rizky Juwita and Sugiharti and Yana Sumpena and Maula Eka and Sri Kartini},
  journal={INDONESIAN JOURNAL OF PHARMACY},
  year={2009},
  pages={55-61}
}
Tuberculosis (TB) is the single most infectious disease, killing millions of people globally. Conventional modalities for TB detection many times the disease is diagnosed at delayed stage and can not use for deep seated infection. Therefore, research and development of 99mTc ethambutol to detect and locate TB at an early stage in any anatomical site have been conducted in PTNBRBATAN Bandung. The result of biological evaluation of 99mTc-ethambutol which studied in rat and mice are as follow… 
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99mTc-ethambutol scintigraphy is a useful diagnostic imaging technique to detect and localize intra- and extra-pulmonary TB and is safe to be performed even in pediatric patient.
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The application of bacterial endotoxin test (BET) using TAL reagent on radiopharmaceutical kits is very important to conduct, and inhibition/enhancement tests for MAA, tetrofosmin, and ethambutol products show non-inhibiting or gel-inducing results, which are in accordance with acceptability standards, so that the samples can be tested using Tal reagents.