Biological effects of recombinant vaccinia virus-expressed interleukin 4.

Abstract

Recombinant vaccinia viruses expressing murine interleukin 4 (IL-4), either alone or together with interleukin 2 (IL-2) or gamma interferon (gamma-IFN), were constructed. Unlike IL-2, IL-4 expressing viruses were not cleared from immunodeficient mice and the mice died. As they died more rapidly than immunodeficient mice inoculated with a control virus, it… (More)

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Cite this paper

@article{Andrew1992BiologicalEO, title={Biological effects of recombinant vaccinia virus-expressed interleukin 4.}, author={Marion E Andrew and Barbara E H Coupar}, journal={Cytokine}, year={1992}, volume={4 4}, pages={281-6} }