Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines.

@article{Brossi1983BiologicalEO,
  title={Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines.},
  author={A. Brossi and P. Sharma and L. Atwell and A. E. Jacobson and M. A. Iorio and M. Molinari and C. Chignell},
  journal={Journal of medicinal chemistry},
  year={1983},
  volume={26 10},
  pages={
          1365-9
        }
}
A series of natural and synthetic colchicine derivatives was examined for their potency in the lymphocytic leukemia P388 screen in mice, for their toxicity in mice, and for their binding to microtubule protein. The natural alkaloids cornigerine and colchifoline and several N,O-substituted analogues of colchifoline were found to be as potent and as toxic as colchicine in the P388 screen with good affinity for tubulin. The 1,2-(methylenedioxy)-substituted isomer of cornigerine was considerably… Expand
31 Citations
Interactions of long-chain homologues of colchicine with tubulin.
Interactions of colchicine with tubulin.
  • S. Hastie
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 1991
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