Biological effects and clinical efficacy of a topical Toll-like receptor 7 agonist in seasonal allergic rhinitis: a parallel group controlled phase IIa study

@article{Greiff2015BiologicalEA,
  title={Biological effects and clinical efficacy of a topical Toll-like receptor 7 agonist in seasonal allergic rhinitis: a parallel group controlled phase IIa study},
  author={Lennart Greiff and Cecilia Ahlstr{\"o}m-Emanuelsson and Mikaela Alen{\"a}s and Gun Almqvist and Morgan Andersson and Anders Cervin and J Dolata and Sam Lindgren and Anders M{\aa}rtensson and Barbara W. Young and Henrik Widegren},
  journal={Inflammation Research},
  year={2015},
  volume={64},
  pages={903-915}
}
Objective and designThe purpose of the study was to examine effects of pre-treatment with a Toll-like receptor 7 (TLR7) agonist (AZD8848) in allergic rhinitis and to evaluate clinical effects of two dosing regimens.SubjectsThe study involved 83 patients with allergic rhinitis. Data on effects of AZD8848 on symptoms were analysed with data from a previous study (n = 68) of identical double blind, parallel group design (NCT00770003).TreatmentThe treatment involved intranasal AZD8848 20 µg three… 
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