Biological effect of tyrosine kinase inhibitors on three canine mast cell tumor cell lines with various KIT statuses.


Tyrosine kinase inhibitors (TKIs) can be important in the treatment of canine mast cell tumor (cMCT). Meanwhile, some TKIs have been identified as substrates for ABCB1. The inhibitory effect of four TKIs (axitinib, imatinib, masitinib, and vatalanib) for proliferation and phosphorylation of c-Kit receptor as well as the expression and function of ABCB1 were… (More)
DOI: 10.1111/j.1365-2885.2011.01296.x


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