Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption.

@article{Nishise2009BiologicalEO,
  title={Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption.},
  author={Shoichi Nishise and Yuji Takeda and Yuko Nishise and Shoichiro Fujishima and Tomohiko Orii and Sayaka Otake and Takeshi Sato and Yu F Sasaki and Hiroaki Takeda and Sumio Kawata},
  journal={Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy},
  year={2009},
  volume={13 6},
  pages={509-14}
}
Anaphylatoxins, which are involved in both pro-inflammatory processes and a variety of anti-inflammatory effects, are produced during granulocyte and monocyte adsorptive apheresis. We noticed the anti-inflammatory effects of C5a, the strongest anaphylatoxin, in granulocyte and monocyte adsorptive apheresis. The aim of this study was to investigate the effect of C5a on interleukin-1 receptor antagonist (IL-1ra) and hepatocyte growth factor (HGF) generation in granulocyte and monocyte adsorption… CONTINUE READING