Biological determinants of endocrine resistance in breast cancer

  title={Biological determinants of endocrine resistance in breast cancer},
  author={Elizabeth A. Musgrove and Robert Lyndsay Sutherland},
  journal={Nature Reviews Cancer},
Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Candidate molecular biomarkers and gene expression signatures of tamoxifen response emphasize the importance of deregulation of proliferation and survival signalling in endocrine resistance. However, definition of the specific genetic lesions and molecular processes… CONTINUE READING
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