Biological data and clinical symptoms as predictors of astrogliosis and neurodegeneration in patients with second-stage Trypanosoma brucei gambiense sleeping sickness.

@article{Lejon2001BiologicalDA,
  title={Biological data and clinical symptoms as predictors of astrogliosis and neurodegeneration in patients with second-stage Trypanosoma brucei gambiense sleeping sickness.},
  author={Veerle Lejon and Dominique Legros and Lars E. Rosengren and M G Gastellu Etchegorry and Philippe B{\"u}scher},
  journal={The American journal of tropical medicine and hygiene},
  year={2001},
  volume={65 6},
  pages={931-5}
}
Concentrations of glial fibrillary acidic protein (GFAp) and light subunit neurofilament protein (NFL) in cerebrospinal fluid (CSF) were measured in patients with second-stage Trypanosoma brucei gambiense sleeping sickness. Correlations between GFAp and NFL in CSF as markers for astrogliosis and neurodegeneration, and clinical and biological data were investigated. Abnormal levels of GFAp and NFL were significantly associated with increasing CSF cell number and protein concentration, and with… CONTINUE READING

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