Corpus ID: 15756663

Biological considerations of tumor-specific and virus-associated antigens of human breast cancers.

@article{Black1976BiologicalCO,
  title={Biological considerations of tumor-specific and virus-associated antigens of human breast cancers.},
  author={Maurice M. Black and Reinhard E. Zachrau and Bella Shore and Henry Patrick Leis},
  journal={Cancer research},
  year={1976},
  volume={36 2 pt 2},
  pages={
          769-74
        }
}
In vivo and in vitro studies bearing on tumor-specific and viral-associated antigenicity of human breast carcinomas were reviewed with particular attention to the following clinical considerations: (a) breast carcinomas arise in a nonrandom fashion; (b) in situ carcinomas precede invasive breast carcinomas; (c) invasive breast carcinomas behave in a heterogeneous fashion. Microscopically demonstrable lymphoreticuloendothelial responses, skin window tests, and leukocyte migration tests all… Expand
Antibodies to mouse mammary tumor virus‐related antigen in sera of patients with breast carcinoma
TLDR
Histopathologic examination of breast cancers indicated that antibodies to antigens in mouse mammary tumors were more often found in patients with infiltrating ductal carcinoma of the mucinous type than with other types of breast tumors. Expand
Cellular immunity to autologous breast cancer and RIII-murine mammary tumor virus preparations.
TLDR
The SW, LMT, and LRE characteristics individually and collectively demonstrate that preinvasive breast cancers are commonly, if not universally, immunogenic; and induced CMI to shared CMI determinants of Stage 0 in situ cancers might exert a retarding influence on subsequently developing breast cancer. Expand
Immunogenicity and MuMTV-like antigenicity of human breast cancer tissues.
  • M. Black
  • Biology, Medicine
  • Contemporary topics in immunobiology
  • 1977
TLDR
There have been a number of reports indicating that some human breast tissues may harbor particles and/or RNA components which resemble murine mammary tumor virus (MuMTV), but it remains to be shown that they are specifically related to the development and/ or behavior of human breast cancers. Expand
Immunological control of breast cancer: discussion.
TLDR
There are several points that came up during this meeting that should be emphasized, particularly with regard to the possible implications for human disease. Expand
Antibody reacting with the murine mammary tumor virus in the serum of patients with breast carcinoma: a possible serological detection method for breast carcinoma.
TLDR
Reactions of human antibodies to MMTV is strongly associated with, but is not entirely specific for, breast carcinoma, and it remains to be determined if normal persons with these antibodies will ultimately develop breast cancer and should be considered at high risk. Expand
Specificity of the simultaneous cell-mediated immune reactivity to RIII murine mammary tumor virus glycoprotein 55 and human breast cancer tissues.
TLDR
It appears that the observed simultaneous LMT reactivity to gp55 and L-RE-positive breast cancer tissues reflects antigenic similarity in their cell-mediated immunity determinants. Expand
Carcinoma‐associated cytostructural antigenic alterations: Detection by lectin binding
TLDR
Tumor cell membrane glycoproteins may be involved in the induction of tumor immunity or in the escape of tumors from immunologic defense mechanisms, in the generation of the immune response to neoplasia. Expand
Biological Markers in Breast Cancer
TLDR
There has been growing interest in the clinical application of immunological assays for the evaluation of patients with cancer, due in part to recent advances in radioimmunoassays (RIAs) and other highly sensitive immunological techniques that allow measurement of picogram or nanogram quantities of antigens. Expand
Assessment of cellular immune response to cancer of the breast.
  • R. Herberman
  • Medicine
  • Annals of clinical and laboratory science
  • 1979
TLDR
Some of the tests for cellular immunity have revealed correlations with clinical course and, therefore, may be of use in the management of patients with breast cancer. Expand
Protein A assay for mouse mammary tumor virus gp52 determinants on murine and human mammary tumor cells.
TLDR
Comparative assays for gp52 cell surface determinants on human and murine mammary tumor cells did not demonstrate gp52-specific binding on five cell lines derived from human breast tumors and one derived from the milk of a lactating woman; however, parallel control GR mammary cultures, assayed on the same day, demonstrated the capability of the assay to detect gp52 determinants. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 42 REFERENCES
Prognostically favorable immunogens of human breast cancer tissue: Antigenic similarity to murine mammary tumor virus
TLDR
The data suggest that immunogens appear in the in situ phase of the disease and provoke prognostically favorable L‐RE responses and these immunogens possess antigenic similarity to some component of MuMTV. Expand
Isolation and identification of soluble skin-reactive membrane antigens of malignant and normal human breast cells.
TLDR
Patients with carcinoma of the breast had delayed hypersensitivity skin reactions to soluble membrane antigens of breast cancer and also to comparable antigen from control breast tissues, which caused skin reactions that were negative with other types of carcinomas. Expand
Cellular responses to autologous breast cancer tissue: Correlation with stage and lymphoreticuloendothelial reactive
TLDR
The findings support previous conclusions regarding the immunologic significance of sinus histiocytosis of axillary lymph nodes and further implicate immunologic phenomena in the biological behavior of human breast carcinoma. Expand
Effect of murine milk samples and human breast tissues on human leukocyte migration indices.
TLDR
The antigenicity of human breast cancer tissue is largely a reflection of a component that is similar to that found in murine mammary tumor virus-infected lactating mammary parenchyma, which is more regularly found among in situ Breast cancer tissues than among invasive breast cancer tissues. Expand
Cellular hypersensitivity to breast cancer. Assessment by a leukocyte migration procedure
TLDR
The data corroborate previous observations on the unique antigenicity of in situ carcinoma and emphasize the need for careful correlations between clinicopathologic findings and in vitro measurements. Expand
Post‐biopsy breast carcinoma: A natural experiment in cancer immunology
TLDR
The findings are consistent with the existence of cross‐reacting immunologic responses in patients with in‐situ breast cancer and raise serious questions regarding the ultimate development of effective immunoprophylaxis or immunotherapy of breast cancer. Expand
Cellular responses to autologous breast cancer tissue. Sequential observations
TLDR
The findings indicate that immunogenicity accompanies the earliest recognizable stages (in situ) of breast carcinoma and that cellular hypersensitivity is an important variable in the biological behavior of breast cancer. Expand
Prognosis in breast cancer utilizing histologic characteristics of the primary tumor
TLDR
A positive association between the cellular responses to areas of in situ carcinoma and the cellular response to accompanying invasive breast cancer is found, adding to the general understanding of immunogenicity of breast cancer tissue. Expand
Further observations on prognostic factors in cancer of the female breast
TLDR
The findings in this study suggest that more intensive study of the dynamic interactions between cancer and the lymphoicticulocndothelial system will provide insight into the behavior of human cancer. Expand
Evidence for viral involvement in murine and human mammary adenocarcinoma.
TLDR
A method involving molecular hybridization with radioactive DNA complementary to the RNA of the mouse mammary tumor virus was used to detect homologous RNA in both murine and human malignant breast tumors. Expand
...
1
2
3
4
5
...