Biological clock: Biological clocks may modulate drug addiction
@article{Yuferov2005BiologicalCB, title={Biological clock: Biological clocks may modulate drug addiction}, author={Vadim P Yuferov and Eduardo R Butelman and Mary Jeanne Kreek}, journal={European Journal of Human Genetics}, year={2005}, volume={13}, pages={1101-1103} }
A recent study by McClung's group (2005),1 expanding on an earlier report,2 provides mechanistic insight to the timekeeper gene, Clock, which may regulate dopaminergic transmission and cocaine reward. This work provides further evidence that cocaine-induced effects have circadian influences.
32 Citations
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- Biology, PsychologyEuropean Journal of Human Genetics
- 2006
The fact that Clock mutant mice are models for both addiction and obesity may be interpreted as evidence that clock genes participate in brain mechanisms that regulate eating and cocaine addiction (eg, pleasure); for example, through a dopamine neurotransmitter system.
Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure
- Biology, PsychologyPloS one
- 2013
Examination of Per gene and Npas2 expression over twenty-four hours identified changes in diurnal rhythmicity of these genes following chronic cocaine, which were regionally specific.
Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN
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It is suggested that drug-entrained rhythms reflect variations in underlying neurophysiological states, which could be the basis for known daily variations in drug metabolism, tolerance, and sensitivity to drug reward.
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- Biology, PsychologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2012
Multiple effects of cocaine on adult circadian clock regulation that are registered within the SCN and involve enhanced serotonergic transmission are revealed.
Circadian rhythms and sleep in bipolar disorder.
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- 2010
There are significant conceptual and empirical limitations on the understanding of a hypothesised link between circadian, sleep, and emotion regulation processes in bipolar disorder.
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- 2019
Pre- and post-nicotine circadian activity rhythms can be differentiated by a paired environmental cue
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- 2008
Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction.
- Psychology, MedicineDrug and alcohol dependence
- 2018
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